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Communication
Complex Gadolinium–Oxo Clusters Formed along Concave Protein Surfaces
Article first published online: 31 AUG 2012
DOI: 10.1002/cbic.201200441
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Veelders, M. and Essen, L.-O. (2012), Complex Gadolinium–Oxo Clusters Formed along Concave Protein Surfaces. ChemBioChem, 13: 2187–2190. doi: 10.1002/cbic.201200441
Publication History
- Issue published online: 5 OCT 2012
- Article first published online: 31 AUG 2012
- Manuscript Received: 29 JUN 2012
Funded by
- DFG. Grant Number: ES152/7
- International Max Planck Research School for environmental, cellular and molecular microbiology
Keywords:
- extracellular cell-wall proteins;
- Gd cluster formation;
- lanthanides;
- MRI contrasting agent;
- X-ray diffraction
Protein-bound contrast: The unusual observation of a heptanuclear gadolinium–oxo cluster on the surface of the cell-adhesion protein Flo5A establishes the basis for directed incorporation of poly-lanthanide clusters into biomolecules. The observed gadolinium cluster might serve as a paradigm for the design of protein-based MRI contrast agents.