Get access

A Shared Biosynthetic Pathway for Botcinins and Botrylactones Revealed through Gene Deletions

Authors

  • Michelli Massaroli,

    1. Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Cádiz (Spain)
    Search for more papers by this author
  • Javier Moraga,

    1. Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Cádiz (Spain)
    Search for more papers by this author
  • Dr. Keyller Bastos Borges,

    1. Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo Institution, 14090-903, Ribeirão Preto (Brazil)
    Search for more papers by this author
  • Jacinto Ramírez-Fernández,

    1. Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Cádiz (Spain)
    Search for more papers by this author
  • Dr. Muriel Viaud,

    1. UMR BIOGER-CPP, INRA Versailles-Grignon, Avenue Lucien Brétignières, 78850 Thiverval-Grignon (France)
    Search for more papers by this author
  • Prof. Dr. Isidro González Collado,

    1. Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Cádiz (Spain)
    Search for more papers by this author
  • Dr. Rosa Durán-Patrón,

    Corresponding author
    1. Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Cádiz (Spain)
    • Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Cádiz (Spain)
    Search for more papers by this author
  • Prof. Dr. Rosario Hernández-Galán

    Corresponding author
    1. Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Cádiz (Spain)
    • Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, 11510 Puerto Real, Cádiz (Spain)
    Search for more papers by this author

Abstract

Isotopic labelling experiments and the study of mutants with disrupted genes encoding botcinic acid have revealed a common link in the biosynthesis of the polyketide toxins excreted by Botrytis cinerea: botcinins and botrylactones. Furthermore, the results reported here shed light on the origin of the starter unit, thereby solving a long-standing mystery in the biosynthesis of botcinins.

Ancillary