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Keywords:

  • bridged nucleic acids;
  • nuclease resistance;
  • oligonucleotides;
  • synthesis design;
  • thermal stability
Thumbnail image of graphical abstract

Towards the next generation: New LNA analogues based on a cyclic amide structure, termed amido-bridged nucleic acids (AmNAs), have been synthesized. Oligonucleotides modified with these residues showed high nuclease resistance along with high binding affinities towards complementary strands.