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Keywords:

  • alkyne–azide click reaction;
  • cysteine;
  • D-recruitment site;
  • non-ATP inhibitors;
  • p38α;
  • polyphenols
Thumbnail image of graphical abstract

A new p38α inhibitor: Using a D-recruitment site (DRS) probe for p38α which exploits covalent interaction with Cys119 and alkyne–azide “click” chemistry to identify small molecules that recognize the p38α DRS, the anti-inflammatory natural product rooperol was identified as a novel p38α inhibitor.