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Keywords:

  • antitumor agents;
  • biological activity;
  • natural products;
  • RNA;
  • splicing
Thumbnail image of graphical abstract

Name your splice: FR901464 analogues and herboxidiene inhibit constitutive splicing, most likely by inhibiting spliceosomal subunit SF3b. A parallel comparison of these compounds in a cell-based assay system showed meayamycin B as the most potent splicing inhibitor among these small molecules.