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Comparison of Splicing Factor 3b Inhibitors in Human Cells

Authors

  • Yang Gao,

    1. Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260 (USA)
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  • Prof. Andreas Vogt,

    1. Department of Computational and Systems Biology, University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, Pennsylvania 15260 (USA)
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  • Prof. Craig J. Forsyth,

    1. Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210 (USA)
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  • Prof. Kazunori Koide

    Corresponding author
    1. Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260 (USA)
    • Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, Pennsylvania 15260 (USA)
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Abstract

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Name your splice: FR901464 analogues and herboxidiene inhibit constitutive splicing, most likely by inhibiting spliceosomal subunit SF3b. A parallel comparison of these compounds in a cell-based assay system showed meayamycin B as the most potent splicing inhibitor among these small molecules.

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