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Communication

A Peptide Photoaffinity Probe Specific for the Active Conformation of the Abl Tyrosine Kinase

  1. Dr. Yang Deng1,
  2. Dr. Brian A. Couch2,
  3. Prof. Anthony J. Koleske2,
  4. Prof. Benjamin E. Turk1,*

Article first published online: 18 OCT 2012

DOI: 10.1002/cbic.201200560

Issue

ChemBioChem

ChemBioChem

Volume 13, Issue 17, pages 2510–2512, November 26, 2012

Additional Information

How to Cite

Deng, Y., Couch, B. A., Koleske, A. J. and Turk, B. E. (2012), A Peptide Photoaffinity Probe Specific for the Active Conformation of the Abl Tyrosine Kinase. ChemBioChem, 13: 2510–2512. doi: 10.1002/cbic.201200560

Author Information

  1. 1

    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520 (USA)

  2. 2

    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 (USA)

*Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520 (USA)

Publication History

  1. Issue published online: 17 NOV 2012
  2. Article first published online: 18 OCT 2012
  3. Manuscript Received: 5 SEP 2012

Funded by

  • National Institutes of Health. Grant Numbers: R21 CA147993, R01 NS39475

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Keywords:

  • activity-based protein profiling;
  • enzymes;
  • phosphopeptides;
  • photoaffinity labeling;
  • protein kinases
Thumbnail image of graphical abstract

An Abl label: The design of sensors to monitor the activity state of specific protein kinases is challenging due to the complexity of eukaryotic kinomes. Here we describe a peptide-based photoaffinity probe that specifically labels the active conformation of the Abl tyrosine kinase.

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