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Keywords:

  • activity-based protein profiling;
  • enzymes;
  • phosphopeptides;
  • photoaffinity labeling;
  • protein kinases
Thumbnail image of graphical abstract

An Abl label: The design of sensors to monitor the activity state of specific protein kinases is challenging due to the complexity of eukaryotic kinomes. Here we describe a peptide-based photoaffinity probe that specifically labels the active conformation of the Abl tyrosine kinase.