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Enhanced Nonenzymatic Ligation of Homopurine Miniduplexes: Support for Greater Base Stacking in a Pre-RNA World

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Abstract

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The ancestors of RNA? There is a long-standing proposal that contemporary nucleic acids might have evolved from RNA-like polymers that utilized only purine–purine base pairs. Here we demonstrate the great advantage that increased nucleobase stacking area provides for nonenzymatic ligation.

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