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Keywords:

  • DNA;
  • drug design;
  • inhibitors;
  • recognition;
  • RNA
Thumbnail image of graphical abstract

Recognition made easy: The selectivity of a small-molecule inhibitor that binds CTG and CUG sites with similar affinity can be shifted toward exclusive CTG recognition by a single N-methylation. Biophysical studies and MD simulations provide insights into the DNA and RNA recognition.