Molecular Diversity Sculpted by Fungal PKS–NRPS Hybrids

Authors

  • Daniela Boettger,

    1. Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11 a, 07745 Jena (Germany)
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  • Christian Hertweck

    Corresponding author
    1. Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11 a, 07745 Jena (Germany)
    2. Chair of Natural Product Research, Friedrich Schiller University, Jena (Germany)
    • Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11 a, 07745 Jena (Germany)
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Abstract

Fungal polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) hybrids manufacture a wide range of structurally diverse secondary metabolites that play an eminent role in the environment, as molecular tools and leads for therapeutic development. To date, a dozen PKS–NRPS megasynthetases can be linked to the corresponding secondary metabolites, which stand out because of their structural complexity. The diversity of their structures, biological activities, and biosynthetic routes are particularly intriguing considering the iterative use of the catalytic domains of the biosynthetic enzymes—implying an enigmatic biosynthetic code. This review provides an overview of the characterized fungal PKS–NRPS hybrids, their manifold functionalities, and the diversity of the resulting secondary metabolites, as well as molecular engineering attempts that highly improved the understanding of their cryptic programming.

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