SEARCH

SEARCH BY CITATION

Keywords:

  • conformation analysis;
  • enzyme promiscuity;
  • enzyme superfamily;
  • evolution;
  • phosphate transfer
Thumbnail image of graphical abstract

Best of both worlds: The interplay of active site reactivity and the dynamic character of proteins allows enzymes to be promiscuous and—sometimes—remarkably efficient at the same time. This review analyses the roles structural flexibility and chemical reactivity play in the catalytic mechanism of selected enzymes.