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Keywords:

  • biosynthesis;
  • cyclization;
  • reaction mechanisms;
  • Streptomyces;
  • terpenoids
Thumbnail image of graphical abstract

Digging up skeletons: We report the identification and the functional characterization of two terpene cyclases (DtcycA and DtcycB) that were mined from the genome of Streptomyces sp. SANK 60404. DtcycA and DtcycB are novel bacterial diterpene cyclases for the synthesis of the cembrane skeleton.