Get access

Synthesis, Duplex Stabilization and Structural Properties of a Fluorinated Carbocyclic LNA Analogue

Authors


Abstract

original image

DNA oligonucleotides modified with nucleoside monomers which have an electron withdrawing group (EWG) at the 2′-position of the furanose ring form more stable duplexes with complementary RNA as compared to unmodified DNA. Here we show that an anti-periplanar orientation of the nucleobase and the 2′-EWG is important for optimal duplex stabilization even for nucleic acid analogues with conformationally locked furanose rings.

Get access to the full text of this article

Ancillary