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Keywords:

  • beta-propeller folds;
  • enzymes;
  • genetic engineering;
  • Kelch repeats;
  • yeast-cell-surface display
Thumbnail image of graphical abstract

Reinventing the wheel: The β-propeller domain folds like a wheel to provide key protein–protein interactions in the cell. Here we used high-throughput yeast sorting to “invent” β-propellers of new binding specificities with cellular targets.