The Impact of Structure on Oxidatively Generated DNA Damage Products Resulting from the C3′-Thymidinyl Radical

Authors

  • Nicholas J. Amato,

    1. Department of Chemistry, The University of Toledo, 2801 W. Bancroft St., Toledo, OH 43606-3390 (USA)
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  • Dr. Amanda C. Bryant-Friedrich

    Corresponding author
    1. Department of Chemistry, The University of Toledo, 2801 W. Bancroft St., Toledo, OH 43606-3390 (USA)
    2. Department of Medicinal and Biological Chemistry, The University of Toledo, 2801 W. Bancroft St., Toledo, OH 43606-3390 (USA)
    • Department of Chemistry, The University of Toledo, 2801 W. Bancroft St., Toledo, OH 43606-3390 (USA)
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Abstract

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What's the damage? Trapping the C3′-thymidinyl radical in biologically significant architectures delivers both the repaired oligomer and 1-(2′-deoxy-β-D-threo-pentofuranosyl)thymidine-containing substrates. The stereoselectivity of the reduction was found to be dependent upon the DNA structure.

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