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Keywords:

  • mass spectrometry;
  • peptide crosslinking;
  • photoactivation;
  • photo-amino acids;
  • protein folding
Thumbnail image of graphical abstract

From folded to crosslinked proteins. A new promising photo-crosslinking/mass spectrometry method for the structural characterisation of folded proteins is highlighted. A reactive photo-leucine can clamp the front residues in β-turn and β-hairpin domains, thus allowing us to look into the specific native 3D structure of proteins.