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Keywords:

  • activity-based protein profiling;
  • enzymes;
  • phosphopeptides;
  • photoaffinity labeling;
  • protein kinases
Thumbnail image of graphical abstract

The inside cover picture shows a peptide photoaffinity label modeled into the active site of the Abl tyrosine kinase. On p. 2510 ff., B. E. Turk et al. show that probes based on Abl substrates label only the active conformation of the kinase. These probes can be used to monitor Abl in complex mixtures and to decipher the mechanisms of action of small-molecule Abl inhibitors.