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Keywords:

  • activity-based probes;
  • diazirines;
  • matrix metalloproteases;
  • metalloenzymes;
  • photoaffinity labeling
Thumbnail image of graphical abstract

The inside cover picture shows the simultaneous labelling under photoirradiation of four MMP catalytic domains with a photoactivable phosphinic MMP inhibitor inside 40 mg of proteome. The specific and sensitive detection of MMP covalent complexes was achieved by radioimaging. For further details see the paper by V. Dive et al. on p. 107 ff.