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The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation

Authors

  • Prof. Morteza Mahmoudi,

    Corresponding author
    1. Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Engelab Street, 14155-6451 Tehran (Iran)
    2. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Engelab Street, 14155-6451 Tehran (Iran)
    • Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Engelab Street, 14155-6451 Tehran (Iran)
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  • Marco P. Monopoli,

    1. Centre for BioNano Interactions, Department of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland)
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  • Meisam Rezaei,

    1. Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Engelab Street, 14155-6451 Tehran (Iran)
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  • Iseult Lynch,

    1. Centre for BioNano Interactions, Department of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland)
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  • Filippo Bertoli,

    1. Centre for BioNano Interactions, Department of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland)
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  • Dr. Jennifer J. McManus,

    Corresponding author
    1. Chemistry Department, National University of Ireland Maynooth, Maynooth, Co. Kildare (Ireland)
    • Chemistry Department, National University of Ireland Maynooth, Maynooth, Co. Kildare (Ireland)
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  • Prof. Kenneth A. Dawson

    Corresponding author
    1. Centre for BioNano Interactions, Department of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland)
    • Centre for BioNano Interactions, Department of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland)
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Abstract

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Put your coat on: It is well recognized that the surfaces of nanomaterials in biological media are covered by various biomolecules (e.g., proteins). A) The protein corona creates a shell over different nanomaterials, regardless of their physicochemical properties (e.g., composition and shape), resulting in reduced levels of amyloid beta fibril formation. B) Pristine nanomaterials might have acceleratory effects on the fibrillation of amyloid beta.

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