SEARCH

SEARCH BY CITATION

Keywords:

  • biocatalysis;
  • polycyclization;
  • promiscuity;
  • squalene–hopene cyclases;
  • terpenoids
Thumbnail image of graphical abstract

Promiscuous enzymes: The substrate promiscuity of squalene–hopene cyclases has been explored and applied in the enzyme-catalyzed synthesis of heterocyclic terpenoids. Features of this work include cyclization reactions without pyrophosphate activation, and stereospecific ring closure of substrates of varying chain length and terminal nucleophile. This provides a biocatalytic alternative to traditional chemical catalysts.