Identification of Novel Sesterterpene/Triterpene Synthase from Bacillus clausii

Authors

  • Prof. Dr. Tsutomu Sato,

    Corresponding author
    1. Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi 2-8050, Nishi-ku, Niigata 950-2181 (Japan)
    • Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi 2-8050, Nishi-ku, Niigata 950-2181 (Japan)

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  • Hiroaki Yamaga,

    1. Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi 2-8050, Nishi-ku, Niigata 950-2181 (Japan)
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  • Shoji Kashima,

    1. Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi 2-8050, Nishi-ku, Niigata 950-2181 (Japan)
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  • Yusuke Murata,

    1. Graduate School of Science, Osaka City University, Sugimoto, Sumiyoshi-ku, Osaka 558-8585 (Japan)
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  • Prof. Dr. Tetsuro Shinada,

    1. Graduate School of Science, Osaka City University, Sugimoto, Sumiyoshi-ku, Osaka 558-8585 (Japan)
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  • Dr. Chiaki Nakano,

    1. Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi 2-8050, Nishi-ku, Niigata 950-2181 (Japan)
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  • Prof. Tsutomu Hoshino

    1. Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science and Technology, Niigata University, Ikarashi 2-8050, Nishi-ku, Niigata 950-2181 (Japan)
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Abstract

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Basic enzyme: The tetraprenyl-β-curcumene synthase homologue from the alkalophilic Bacillus clausii catalyses conversions of a geranylfarnesyl diphosphate and a hexaprenyl diphosphate into novel head-to-tail acyclic sesterterpene and triterpene. Tetraprenyl-β-curcumene synthase homologues represent a new family of terpene synthases that form not only sesquarterpene but also sesterterpene and triterpene.

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