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Keywords:

  • 5-hydroxylmethylcytosine;
  • DNA methylation;
  • epigenetics;
  • nanopores;
  • nonenzymatic labeling
Thumbnail image of graphical abstract

Labeling chemically for a “single” result: A one-step, nonenzymatic 5hmC thiolation method mediated by bisulfite is highlighted. The 5hmC base can be chemically labeled in single-stranded DNA and detected by using nanopore sequencing.