Comparative Metabolomic Analysis of an Alternative Biosynthetic Pathway to Pseudosugars in Actinosynnema mirum DSM 43827

Authors

  • Dr. Shumpei Asamizu,

    1. Department of Pharmaceutical Sciences, Oregon State University, 203 Pharmacy Building, Corvallis, Oregon 97331 (USA)
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  • Mostafa Abugreen,

    1. Department of Pharmaceutical Sciences, Oregon State University, 203 Pharmacy Building, Corvallis, Oregon 97331 (USA)
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  • Prof. Dr. Taifo Mahmud

    Corresponding author
    1. Department of Pharmaceutical Sciences, Oregon State University, 203 Pharmacy Building, Corvallis, Oregon 97331 (USA)
    • Department of Pharmaceutical Sciences, Oregon State University, 203 Pharmacy Building, Corvallis, Oregon 97331 (USA)===

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Abstract

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Through a combination of genome mining, gene knockouts, and comparative metabolomic studies, a new biosynthetic pathway to validoxylamine A has been discovered in Actinosynnema mirum DSM 43827. The study revealed the rich diversity of biosynthetic pathways to pseudosugar-containing natural products.

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