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Multiple Oxidative Routes towards the Maturation of Nosiheptide

Authors

  • Weiying Liu,

    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (P.R. China)
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  • Yanjiu Xue,

    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (P.R. China)
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  • Min Ma,

    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (P.R. China)
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  • Dr. Shuzhen Wang,

    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (P.R. China)
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  • Dr. Nan Liu,

    Corresponding author
    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (P.R. China)
    • State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (P.R. China)===

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  • Prof. Dr. Yijun Chen

    Corresponding author
    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (P.R. China)
    • State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (P.R. China)===

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Abstract

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Three oxidative routes: Two cytochrome P450-like mono-oxygenases cooperate in the biosynthesis of nosiheptide (Nos): NosB catalyzes hydroxylation of the Glu6 γ-position, whereas NosC hydroxylates the Pyr3 position, thus enabling cleavage of the bis-Dha tail by NosA. Combining the polysubstrate specificity of NosB and NosC and the function of NosA generates three oxidative routes in nosiheptide maturation.

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