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Keywords:

  • chemical dimerizers;
  • chemically induced dimerization;
  • signal transduction;
  • small molecules
Thumbnail image of graphical abstract

Switch on and off: Chemically induced dimerization (CID) has been shown to be a powerful tool for dissecting and emulating signaling pathways. What has been missing so far is the reproduction of reversibility in signal transduction. This problem could be resolved by applying two orthogonal CID systems in tandem, which allow switching signaling on and off through a double translocation strategy.