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Exploring Adenylylation and Phosphocholination as Post-Translational Modifications

Authors

  • Dr. Matthias P. Müller,

    1. Department of Physical Biochemistry, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)
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  • Michael F. Albers,

    1. Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)
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  • Prof. Dr. Aymelt Itzen,

    Corresponding author
    1. Department of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Technische Universität München, Lichtenbergstrasse 4, 85747 Garching (Germany)
    • Aymelt Itzen, Department of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Technische Universität München, Lichtenbergstrasse 4, 85747 Garching (Germany)===

      Christian Hedberg, Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)===

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  • Dr. Christian Hedberg

    Corresponding author
    1. Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)
    • Aymelt Itzen, Department of Chemistry, Center for Integrated Protein Science Munich (CIPSM), Technische Universität München, Lichtenbergstrasse 4, 85747 Garching (Germany)===

      Christian Hedberg, Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227 Dortmund (Germany)===

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Abstract

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Editing the translations: Adenylylation and phosphocholination have recently been found as important post-translational modifications used by pathogenic bacteria during the infection process. This review discusses the combined use of chemical handles and specific antibodies for the identification of previously unknown substrates of these post-translational modifications in infected host cells.

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