Bifacial PNA Complexation Inhibits Enzymatic Access to DNA and RNA

Authors

  • Xin Xia,

    1. Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA)
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  • Xijun Piao,

    1. Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA)
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  • Prof. Kurt Fredrick,

    1. Department of Microbiology, The Ohio State University, 286 Aronoff, 376 Biological Sciences Building, 484 West 12th Avenue, Columbus, OH 43210-1292 (USA)
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  • Prof. Dennis Bong

    Corresponding author
    1. Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA)
    • Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA)===

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Abstract

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Full stop: Herein we report the effective in vitro inhibition of transcription, reverse-transcription and exonuclease function by formation of synthetic bPNA–nucleic acid triplex structures. Selective bPNA targeting of both DNA and RNA substrates suggests possible application of bPNAs as synthetic regulators of nucleic acid function.

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