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New Biologically Active Hydrogen Sulfide Donors

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Abstract

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Generous donors: The dithioperoxyanhydrides (CH3COS)2, (PhCOS)2, CH3COSSCO2Me and PhCOSSCO2Me act as thiol-activated hydrogen sulfide donors in aqueous buffer solution. The most efficient donor (CH3COS)2 can induce a biological response in cells, and advantageously replace hydrogen sulfide in ex vivo vascular studies.

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