SEARCH

SEARCH BY CITATION

Keywords:

  • biosynthesis;
  • branching;
  • polyketides;
  • rhizoxin
Thumbnail image of graphical abstract

The PKS tree gets a new branch: Hertweck and co-workers have uncovered the enzymology behind the novel β-branching strategy used during Rhizoxin biosynthesis in Burholderia rhizoxinica. Both the KS and B domains are required for a δ-lactone to form by attack on the pre-existing polyketide chain; further chain extension must occur on the newly added β-branching carbonyl.