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On One Leg: Trehalose Monoesters Activate Macrophages in a Mincle-Dependent Manner

Authors

  • Dr. Bridget L. Stocker,

    Corresponding author
    1. School of Chemical and Physical Sciences, Victoria University of Wellington, P. O. Box 600, 6140 Wellington (New Zealand)
    2. Malaghan Institute of Medical Research, P. O. Box 7060, 6242 Wellington (New Zealand)
    • School of Chemical and Physical Sciences, Victoria University of Wellington, P. O. Box 600, 6140 Wellington (New Zealand)

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  • Dr. Ashna A. Khan,

    1. School of Chemical and Physical Sciences, Victoria University of Wellington, P. O. Box 600, 6140 Wellington (New Zealand)
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  • Stephanie H. Chee,

    1. School of Chemical and Physical Sciences, Victoria University of Wellington, P. O. Box 600, 6140 Wellington (New Zealand)
    2. Malaghan Institute of Medical Research, P. O. Box 7060, 6242 Wellington (New Zealand)
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  • Dr. Faustin Kamena,

    1. Max Planck Institute for Infection Biology, Department of Parasitology, Charitéplatz 1, 10117 Berlin (Germany)
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  • Dr. Mattie S. M. Timmer

    Corresponding author
    1. School of Chemical and Physical Sciences, Victoria University of Wellington, P. O. Box 600, 6140 Wellington (New Zealand)
    • School of Chemical and Physical Sciences, Victoria University of Wellington, P. O. Box 600, 6140 Wellington (New Zealand)

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Abstract

The C22 and C26 trehalose monoesters, each containing a single acyl chain, were synthesised in good overall yields and found to activate macrophages in a Mincle-dependent manner. The activities of the monoesters paralleled those of their diester counterparts, and both mono- and diesters could activate the immune response in the absence of priming. This is the first time that trehalose monoesters have been found to activate macrophages, and these studies thus provide an important framework for the rational design of other Mincle agonists.

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