The Selenocysteine Incorporation Machinery Allows the Dual Use of Sense Codons: A New Strategy for Expanding the Genetic Code?
Article first published online: 20 DEC 2013
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Volume 15, Issue 3, pages 356–358, February 10, 2014
How to Cite
Stafforst, T. (2014), The Selenocysteine Incorporation Machinery Allows the Dual Use of Sense Codons: A New Strategy for Expanding the Genetic Code?. ChemBioChem, 15: 356–358. doi: 10.1002/cbic.201300735
- Issue published online: 2 FEB 2014
- Article first published online: 20 DEC 2013
- Manuscript Received: 22 NOV 2013
- DFG. Grant Number: STA 1053/3-1
- genetic code;
- seleno proteins;
Sense and Secis: Even though selenocysteine, Sec, is naturally incorporated by suppressing UAG stop codons, it was recently shown that sense codons such as UAC can efficiently code for Sec. This article highlights the implications of using such a strategy to introduce unnatural amino acids site-selectively into proteins. Please note: ChemBioChem will be accepting submissions of original research for a special issue on “Expanding the Genetic Code” in January 2014.