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The Selenocysteine Incorporation Machinery Allows the Dual Use of Sense Codons: A New Strategy for Expanding the Genetic Code?



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Sense and Secis: Even though selenocysteine, Sec, is naturally incorporated by suppressing UAG stop codons, it was recently shown that sense codons such as UAC can efficiently code for Sec. This article highlights the implications of using such a strategy to introduce unnatural amino acids site-selectively into proteins. Please note: ChemBioChem will be accepting submissions of original research for a special issue on “Expanding the Genetic Code” in January 2014.