The inside cover picture shows the oligomerization of activated RNA monomers by the catalytic dipeptide Ser-His. On p. 217 ff., P.-A. Monnard et al. explain how the reaction takes place in a water/ice eutectic phase below 0 °C. This reaction environment is believed to be prebiotically plausible and likely present today on various planetary bodies like the moon Europa (background photograph: NASA, http://photojournal.jpl.nasa.gov).