Inside Cover: Formation of RNA Phosphodiester Bond by Histidine-Containing Dipeptides (ChemBioChem 2/2013)

Authors

  • Dr. Rafał Wieczorek,

    1. FLinT Center, Institut for Fysik, Kemi og Farmaci (IFKF), University of Southern Denmark, Campusvej 55, 5230 Odense (Denmark)
    2. Dipartimento di Biologia, Università degli Studi di Roma Tre, Viale Guglielmo Marconi 446, 00146 Rome (Italy)
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  • Dr. Mark Dörr,

    1. FLinT Center, Institut for Fysik, Kemi og Farmaci (IFKF), University of Southern Denmark, Campusvej 55, 5230 Odense (Denmark)
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  • Agata Chotera,

    1. FLinT Center, Institut for Fysik, Kemi og Farmaci (IFKF), University of Southern Denmark, Campusvej 55, 5230 Odense (Denmark)
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  • Prof. Pier Luigi Luisi,

    1. Dipartimento di Biologia, Università degli Studi di Roma Tre, Viale Guglielmo Marconi 446, 00146 Rome (Italy)
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  • Dr. Pierre-Alain Monnard

    Corresponding author
    1. FLinT Center, Institut for Fysik, Kemi og Farmaci (IFKF), University of Southern Denmark, Campusvej 55, 5230 Odense (Denmark)
    • FLinT Center, Institut for Fysik, Kemi og Farmaci (IFKF), University of Southern Denmark, Campusvej 55, 5230 Odense (Denmark)
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Abstract

original image

The inside cover picture shows the oligomerization of activated RNA monomers by the catalytic dipeptide Ser-His. On p. 217 ff., P.-A. Monnard et al. explain how the reaction takes place in a water/ice eutectic phase below 0 °C. This reaction environment is believed to be prebiotically plausible and likely present today on various planetary bodies like the moon Europa (background photograph: NASA, http://photojournal.jpl.nasa.gov).

Cartoon 1.

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