Cover Picture: The Protein Corona Mediates the Impact of Nanomaterials and Slows Amyloid Beta Fibrillation (ChemBioChem 5/2013)

Authors

  • Prof. Morteza Mahmoudi,

    Corresponding author
    1. Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Engelab Street, 14155-6451 Tehran (Iran)
    2. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Engelab Street, 14155-6451 Tehran (Iran)
    • Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Engelab Street, 14155-6451 Tehran (Iran)
    Search for more papers by this author
  • Marco P. Monopoli,

    1. Centre for BioNano Interactions, Department of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland)
    Search for more papers by this author
  • Meisam Rezaei,

    1. Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Engelab Street, 14155-6451 Tehran (Iran)
    Search for more papers by this author
  • Iseult Lynch,

    1. Centre for BioNano Interactions, Department of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland)
    Search for more papers by this author
  • Filippo Bertoli,

    1. Centre for BioNano Interactions, Department of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland)
    Search for more papers by this author
  • Dr. Jennifer J. McManus,

    Corresponding author
    1. Chemistry Department, National University of Ireland Maynooth, Maynooth, Co. Kildare (Ireland)
    • Chemistry Department, National University of Ireland Maynooth, Maynooth, Co. Kildare (Ireland)
    Search for more papers by this author
  • Prof. Kenneth A. Dawson

    Corresponding author
    1. Centre for BioNano Interactions, Department of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland)
    • Centre for BioNano Interactions, Department of Chemistry and Chemical Biology, University College Dublin, Belfield, Dublin 4 (Ireland)
    Search for more papers by this author

Abstract

original image

The cover picture shows that the presence of the protein corona at the surface of nanomaterials inhibits the fibrillation process of amyloid beta (Aβ) monomers. Several different nanomaterials [i.e., silica (100 and 200 nm), polystyrene with carboxyl surface modification (100 nm), and multi-walled carbon nanotubes (10–40 nm in diameter and 0.1–10 mm in length)] were used, and their effects on the Aβ fibrillation process were probed in the absence and presence of a protein corona, as well as well as under conditions under whic the protein corona was denatured. In their communication on p. 568 ff., M. Mahmoudi, J. J. McManus, K. A. Dawson, et al. show that the protein corona creates a shell at the surface of nanomaterials, regardless of their physico-chemical properties (e.g., size, core composition, shape, and surface properties), that reduces the levels of Aβ fibril formation.

Cartoon 1.

Ancillary