Inside Cover: The C-Terminal Extended Serine Residue Is Absolutely Required in Nosiheptide Maturation (ChemBioChem 5/2013)

Authors

  • Weiying Liu,

    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (PRC)
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  • Min Ma,

    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (PRC)
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  • Yanjiu Xue,

    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (PRC)
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  • Dr. Nan Liu,

    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (PRC)
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  • Dr. Shuzhen Wang,

    Corresponding author
    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (PRC)
    • State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (PRC)
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  • Prof. Dr. Yijun Chen

    Corresponding author
    1. State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (PRC)
    • State Key Laboratory of Natural Medicines and Laboratory of Chemical Biology, China Pharmaceutical University, 24 Tongjia Street, Nanjing, Jiangsu Province, 210009 (PRC)
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Abstract

original image

The inside cover picture shows the necessity of the extended Ser13 residue of the core peptide in the process of nosiheptide maturation; this residue cannot be replaced by other amino acids without loss of function. For more details, see the paper by S. Wang, Y. Chen, et al. on p. 573 ff.

Cartoon 1.

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