Inside Cover: Bicyclic Peptide Inhibitor of Urokinase-Type Plasminogen Activator: Mode of Action (ChemBioChem 16/2013)

Authors

  • Dr. Renée Roodbeen,

    1. Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)
    2. Department of Chemistry, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C (Denmark)
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  • Berit Paaske,

    1. Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)
    2. Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C (Denmark)
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  • Longguang Jiang,

    1. Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)
    2. Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yang Qiao West Road, Fuzhou 350002 (China)
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  • Dr. Jan K. Jensen,

    1. Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)
    2. Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, 8000 Aarhus C (Denmark)
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  • Anni Christensen,

    1. Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)
    2. Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, 8000 Aarhus C (Denmark)
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  • Dr. Jakob T. Nielsen,

    1. Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)
    2. Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C (Denmark)
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  • Prof. Dr. Mingdong Huang,

    1. Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)
    2. Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yang Qiao West Road, Fuzhou 350002 (China)
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  • Prof. Frans A. A. Mulder,

    1. Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C (Denmark)
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  • Prof. Dr. Niels Chr. Nielsen,

    1. Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)
    2. Center for Insoluble Protein Structures (inSPIN), Interdisciplinary Nanoscience Center (iNANO) and Department of Chemistry, Aarhus University, Gustav Wieds Vej 14, 8000 Aarhus C (Denmark)
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  • Prof. Dr. Peter A. Andreasen,

    1. Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)
    2. Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, 8000 Aarhus C (Denmark)
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  • Prof. Dr. Knud J. Jensen

    Corresponding author
    1. Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)
    2. Department of Chemistry, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C (Denmark)
    • Danish-Chinese Centre for Proteases and Cancer, Aarhus University, 10C Gustav Wieds Vej, 8000 Aarhus C (Denmark)

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Abstract

original image

The inside cover picture shows the binding of a rationally designed bicyclic peptide inhibitor to the serine protease urokinase-type plasminogen activator (uPA). On p. 2179 ff., K. J. Jensen et al. describe how a monocyclic peptide was transformed into a bicyclic peptide without loss of inhibitory properties but, rewardingly, with a reduced loss of entropy upon binding.

Cartoon 1.

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