Macro and Small over Micro: Macromolecules and Small Molecules that Regulate MicroRNAs

Authors

  • Soowon Kang,

    1. Department of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756 (Korea)
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    • These authors contributed equally to this work.

  • Kyungtaek Im,

    1. Department of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756 (Korea)
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    • These authors contributed equally to this work.

  • Jihae Baek,

    1. Department of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756 (Korea)
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  • Prof. Sungroh Yoon,

    1. Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-744 (Korea)
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  • Prof. Hyeyoung Min

    Corresponding author
    1. Department of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756 (Korea)
    • Department of Pharmacy, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul 156-756 (Korea)===

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Abstract

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Given the correlation between the deregulation of specific miRNAs and disease onset, it is critical to identify miRNA regulators that effectively control miRNAs involved in the pathogenesis of target diseases. This review provides the latest update on oligonucleotide- and small-molecule-based miRNA regulators, and discusses assays developed to screen for small-molecule regulators.

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