Get access

Crystal Structures of Acyl Carrier Protein in Complex with Two Catalytic Partners Show a Dynamic Role in Cellular Metabolism

Authors

  • Dr. Sean A. Newmister,

    1. Life Sciences Institute, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA)
    Search for more papers by this author
  • Prof. David H. Sherman

    Corresponding author
    1. Life Sciences Institute and Departments of Medicinal Chemistry, Chemistry, and Microbiology & Immunology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA)
    • Life Sciences Institute and Departments of Medicinal Chemistry, Chemistry, and Microbiology & Immunology, University of Michigan, 210 Washtenaw Avenue, Ann Arbor, MI 48109 (USA)===

    Search for more papers by this author

Abstract

original image

ACP captured in action: Two recently reported crystal structures are the first to capture ACP-mediated substrate delivery to a catalytic partner at high resolution. These studies highlight key interactions of transient ACP–partner complexes and define the dynamic movements of ACP that facilitate substrate delivery and trigger complex dissociation.

Ancillary