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Keywords:

  • biosynthesis;
  • gene expression;
  • genome mining;
  • tetronates;
  • transcription factors
Thumbnail image of graphical abstract

Induced production of tetronate derivatives: We activated a dormant PKS-NRPS gene cluster in Aspergillus niger ATCC 1015 by expressing its dedicated transcription activator (caaR). As a result, the transformant expressing caaR produces three acyltetronate derivatives: carlosic acid (1), agglomerin F (2), and carlosic acid methyl ester (3).