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Three Acyltetronic Acid Derivatives: Noncanonical Cryptic Polyketides from Aspergillus niger Identified by Genome Mining

Authors

  • Dr. Xiao-Long Yang,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 (Japan)
    2. College of Pharmaceutical Science, Hebei University, Baoding 071002 (P. R. China)
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  • Dr. Takayoshi Awakawa,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 (Japan)
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  • Dr. Toshiyuki Wakimoto,

    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 (Japan)
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  • Prof. Dr. Ikuro Abe

    Corresponding author
    1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 (Japan)
    • Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033 (Japan)===

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Abstract

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Induced production of tetronate derivatives: We activated a dormant PKS-NRPS gene cluster in Aspergillus niger ATCC 1015 by expressing its dedicated transcription activator (caaR). As a result, the transformant expressing caaR produces three acyltetronate derivatives: carlosic acid (1), agglomerin F (2), and carlosic acid methyl ester (3).

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