Replicating an Expanded Genetic Alphabet in Cells

Authors

  • Prof. Dr. John C. Chaput

    Corresponding author
    1. Center for Evolutionary Medicine and Bioinformatics, The Biodesign Institute, Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287-5301 (USA)
    • Center for Evolutionary Medicine and Bioinformatics, The Biodesign Institute, Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287-5301 (USA)

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Abstract

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Recent advances in synthetic biology have made it possible to replicate an unnatural base pair in living cells. This study highlights the technologies developed to create a semisynthetic organism with an expanded genetic alphabet and the potential challenges of moving forward.

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