Of Two Make One: The Biosynthesis of Phenazines (pages 2295–2304)
Matthias Mentel, Ekta G. Ahuja, Dmitri V. Mavrodi, Rolf Breinbauer, Linda S. Thomashow and Wulf Blankenfeldt
Article first published online: 5 AUG 2009 | DOI: 10.1002/cbic.200900323
Five easy steps: Phenazines are redox-active bacterial secondary metabolites that possess broad-specificity antibiotic activity and can also play an important role as virulence factors in infectious disease. Their biosynthesis from two molecules of chorismic acid is catalyzed by enzymes encoded in the conserved phz operon.