The Influence of Ligand Valency on Aggregation Mechanisms for Inhibiting Bacterial Toxins (pages 329–337)
Cristina Sisu, Andrew J. Baron, Hilbert M. Branderhorst, Simon D. Connell, Carel A. G. M. Weijers, Renko de Vries, Edward D. Hayes, Aliaksei V. Pukin, Michel Gilbert, Roland J. Pieters, Han Zuilhof, Gerben M. Visser and W. Bruce Turnbull
Article first published online: 25 NOV 2008 | DOI: 10.1002/cbic.200800550
Mastering multivalency: Multivalency is widely exploited for increasing the activity of inhibitors against multimeric proteins. Here we show that the valency of the inhibitor also has a dramatic effect on the kinetics of aggregation and the stability of intermediate protein complexes.