Low pH-Triggered Model Drug Molecule Release from Virus-Like Particles (pages 959–962)
Noriko Ohtake, Kenichi Niikura, Tadaki Suzuki, Keita Nagakawa, Shintaro Mikuni, Yasutaka Matsuo, Masataka Kinjo, Hirofumi Sawa and Kuniharu Ijiro
Version of Record online: 16 MAR 2010 | DOI: 10.1002/cbic.201000094
Let it go: Virus-like particles (VLPs) incorporating a peptide-tag were constructed. Fluorescent dye molecules attached to nitrilotriacetic acid (NTA) were encapsulated within the VLPs as model drug molecules by using the affinity between a hexahistidine motif (His6) and NTA. The model drug molecules were released under acidic conditions due to the protonation of histidines.