N-Methyl-Substituted Fluorescent DAG–Indololactone Isomers Exhibit Dramatic Differences in Membrane Interactions and Biological Activity (pages 2331–2340)
Noga Gal, Dr. Sofiya Kolusheva, Dr. Noemi Kedei, Dr. Andrea Telek, Taiyabah A. Naeem, Nancy E. Lewin, Langston Lim, Poonam Mannan, Susan H. Garfield, Dr. Saïd El Kazzouli, Dr. Dina M. Sigano, Dr. Victor E. Marquez, Dr. Peter M. Blumberg and Prof. Raz Jelinek
Version of Record online: 16 AUG 2011 | DOI: 10.1002/cbic.201100246
Bound up: We have analyzed the membrane interactions and biological activities of several diacylglycerol–indololactones (DAG–indololactones). The positional isomers of the tested compounds were found to exhibit pronounced differences in their PKC translocation activities and their interactions with lipid bilayers (see figure).