Cyclic RGD β-Lactam Peptidomimetics Induce Differential Gene Expression in Human Endothelial Cells (pages 401–405)
Prof. Dr. Jesus M. Aizpurua, Prof. Dr. José Ignacio Ganboa, Prof. Dr. Claudio Palomo, Dr. Iraida Loinaz, Dr. Joseba Oyarbide, Xabier Fernandez, Dr. Eva Balentová, Dr. Raluca M. Fratila, Dr. Azucena Jiménez, Dr. José Ignacio Miranda, Dr. Antonio Laso, Dr. Silvia Ávila and Dr. José Luis Castrillo
Article first published online: 10 JAN 2011 | DOI: 10.1002/cbic.201000572
RGD peptidomimetics touch DNA: A few RGD cyclic peptidomimetics, each incorporating a densely substituted β-lactam moiety, were prepared, and their effect on extracellular adhesion and intracellular gene regulation through αVβ3 integrin was studied in human endothelial cells (HUVECs). Surprisingly, the cyclic tetrapeptide with a deleted glycine residue and its parent RGD peptidomimetic displayed practically opposite angiogenic gene-regulation activity.