SSTR1- and SSTR3-Selective Somatostatin Analogues (pages 625–632)
Dr. Rosario Ramón , Pablo Martín-Gago, Prof. Xavier Verdaguer , Prof. Maria J. Macias , Pau Martin-Malpartida, Dr. Jimena Fernández-Carneado, Marc Gomez-Caminals, Dr. Berta Ponsati, Prof. Pilar López-Ruiz, Maria Alicia Cortés, Begoña Colás and Prof. Antoni Riera
Version of Record online: 21 JAN 2011 | DOI: 10.1002/cbic.201000597
Flexible strength: The two enantiomers of amino acid 3-(3′-quinolyl)alanine (Qla) have been synthesized. They were then used in the synthesis of two Somatostatin analogues that exhibit strong affinity to receptors SSTR1 and SSTR3. The conformational flexibility of these peptides, greater than that of Somatostatin, might be beneficial to the interaction with the receptors.