Mechanism of Action of the Cytotoxic Macrolides Amphidinolide X and J (pages 1027–1030)
Chiara Trigili, Benet Pera, Dr. Marion Barbazanges, Prof. Dr. Janine Cossy, Dr. Christophe Meyer, Dr. Oriol Pineda, Dr. Carles Rodríguez-Escrich, Prof. Fèlix Urpí, Prof. Dr. Jaume Vilarrasa, Dr. J. Fernando Díaz and Dr. Isabel Barasoain
Article first published online: 15 APR 2011 | DOI: 10.1002/cbic.201100042
Acting on actin: The mechanism of action of amphidinolide X and amphidinolide J, two relatively small cytotoxic macrolides, has been elucidated. They do not target microtubules and intermediate filaments. The effects observed in A549 and PtK2 cells and the in vitro interaction with actin monomer (G-actin) indicate that these macrolides behave as actin-assembly inhibitors.