Multifunctions of MelB, a Fungal Tyrosinase from Aspergillus oryzae (pages 193–201)
Dr. Nobutaka Fujieda, Michiaki Murata, Shintaro Yabuta, Takuya Ikeda, Dr. Chizu Shimokawa, Dr. Yukihiro Nakamura, Dr. Yoji Hata and Prof. Shinobu Itoh
Article first published online: 30 DEC 2011 | DOI: 10.1002/cbic.201100609
Proteolytic functional change: the melB gene product (melB tyrosinase) from Aspergillus oryzae can function as dioxygen carrier, monooxygenase, and oxidase. The cleavage of the C-terminal domain by proteolytic treatment changes the function of the tyrosinase from dioxygen carrier to catechol oxidase and phenol monooxygenase.